作者
Jeong-Eun Lee, Pyong-Gon Moon, Young-Eun Cho, Young-Bum Kim, In-San Kim, Hoyong Park, Moon-Chang Baek
发表日期
2016/1/10
期刊
Journal of proteomics
卷号
131
页码范围
17-28
出版商
Elsevier
简介
Cancer cell-derived extracellular vesicles have been linked to the pathogenesis of various cancers; however, the role of extracellular vesicles in tumorigenesis remains unclear. To identify extracellular vesicle proteins involved in cancer metastasis, quantitative proteomic analyses were performed on extracellular vesicles derived from two representative breast cancer cell lines: the less invasive MCF-7 and the invasive MDA-MB-231. Proteomic analysis allowed for the identification of 270 proteins in the extracellular vesicles. Here we report a new function of EDIL3 on extracellular vesicles, which are sufficient for enhancement of cell invasion and for acceleration of lung metastasis in vivo. This invasion is most likely mediated via the integrin-FAK signaling cascade in breast cancer cells. However, these effects are suppressed when EDIL3 is inactivated, providing evidence for a critical role of EDIL3 in development of …
学术搜索中的文章
JE Lee, PG Moon, YE Cho, YB Kim, IS Kim, H Park… - Journal of proteomics, 2016