作者
Charles N Agoti, Martin D Curran, Nickson Murunga, Moses Ngari, Esther Muthumbi, Arnold W Lambisia, Simon DW Frost, Barbara A Blacklaws, D James Nokes, Lydia N Drumright
发表日期
2022/8/1
期刊
Gut Pathogens
卷号
14
期号
1
页码范围
32
出版商
BioMed Central
简介
Background
Kenya introduced Rotarix® (GlaxoSmithKline Biologicals, Rixensart, Belgium) vaccination into its national immunization programme beginning July 2014. The impact of this vaccination program on the local epidemiology of various known enteropathogens is not fully understood.
Methods
We used a custom TaqMan Array Card (TAC) to screen for 28 different enteropathogens in 718 stools from children aged less than 13 years admitted to Kilifi County Hospital, coastal Kenya, following presentation with diarrhea in 2013 (before vaccine introduction) and in 2016–2018 (after vaccine introduction). Pathogen positivity rate differences between pre- and post-Rotarix® vaccination introduction were examined using both univariate and multivariable logistic regression models.
Results
In 665 specimens (92.6%), one or more enteropathogen was detected, while in 323 specimens (48.6%) three or more …
学术搜索中的文章
CN Agoti, MD Curran, N Murunga, M Ngari… - Gut Pathogens, 2022