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The gene expression profiles of benign and malignant adrenocortical tumors are different.

Genomewide gene expression profiling and validation.

Tertiary medical center.

Eighty-five patients with benign adrenocortical tumors (n = 74) and adrenocortical carcinoma (n = 11).

Real-time quantitative reverse transcription–polymerase chain reaction (RT-PCR) in 89 adrenocortical tissue samples (11 malignant and 78 benign). The criteria for differentially expressed genes between benign and malignant adrenocortical tumors were a false discovery rate of less than 5% and an adjustedP < .01. Genes differentially expressed by 8-fold higher or lower were validated by RT-PCR.

The diagnostic accuracy of differentially expressed genes as determined by the area under the receiver operating characteristic curve (AUC).

We found 37 genes differentially …