作者
Mark Zhu, Mei Lin Tay, Khoon S Lim, Scott M Bolam, Donna Tuari, Karen Callon, Michael Dray, Jillian Cornish, Tim BF Woodfield, Jacob T Munro, Brendan Coleman, David S Musson
发表日期
2022/3
期刊
The American Journal of Sports Medicine
卷号
50
期号
4
页码范围
1044-1053
出版商
SAGE Publications
简介
Background
The lack of healing at the repaired tendon-bone interface is an important cause of failure after rotator cuff repair. While augmentation with growth factors (GFs) has demonstrated promise, the ideal combination must target all 3 tissue types at the tendon-bone interface.
Hypothesis
The GF combination of transforming growth factor beta 1, Insulin-like growth factor 1, and parathyroid hormone will promote tenocyte proliferation and differentiation and improve the biomechanical and histological quality of the repaired tendon-bone interface.
Study Design
Controlled laboratory study.
Methods
In vitro, human tenocytes were cultured in the presence of the GF combination for 72 hours, and cell growth assays and the expression of genes specific to tendon, cartilage, and bone were analyzed. In vivo, adult rats (N = 46) underwent detachment and repair of the left supraspinatus tendon. A PVA-tyramine gel was used to …
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M Zhu, M Lin Tay, KS Lim, SM Bolam, D Tuari, K Callon… - The American Journal of Sports Medicine, 2022