作者
Scott M Bolam, Young-Eun Park, Subhajit Konar, Karen E Callon, Josh Workman, A Paul Monk, Brendan Coleman, Jillian Cornish, Mark H Vickers, Jacob T Munro, David S Musson
发表日期
2021/12
期刊
The American Journal of Sports Medicine
卷号
49
期号
14
页码范围
3959-3969
出版商
SAGE Publications
简介
Background
Being overweight or obese is associated with poor outcomes and an increased risk of failure after rotator cuff (RC) surgery. However, the effect of obesity on enthesis healing has not been well characterized.
Hypotheses
Diet-induced obesity (DIO) would result in inferior enthesis healing in a rat model of RC repair, and a dietary intervention in the perioperative period would improve enthesis healing.
Study Design
Controlled laboratory study.
Methods
Male Sprague-Dawley rats were divided into 3 weight-matched groups (n = 26 per group): control diet (CD), high-fat diet (HFD), or HFD until surgery and then CD thereafter (HF-CD). After 12 weeks, the left supraspinatus tendon was detached, followed by immediate repair. Animals were sacrificed, and RCs were harvested at 2 and 12 weeks after surgery for biomechanical and histological evaluations. Metabolic end points were assessed using dual-energy X …
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SM Bolam, YE Park, S Konar, KE Callon, J Workman… - The American Journal of Sports Medicine, 2021