作者
Amit V Khera, Connor A Emdin, Isabel Drake, Pradeep Natarajan, Alexander G Bick, Nancy R Cook, Daniel I Chasman, Usman Baber, Roxana Mehran, Daniel J Rader, Valentin Fuster, Eric Boerwinkle, Olle Melander, Marju Orho-Melander, Paul M Ridker, Sekar Kathiresan
发表日期
2016/12/15
期刊
New England Journal of Medicine
卷号
375
期号
24
页码范围
2349-2358
出版商
Massachusetts Medical Society
简介
Background
Both genetic and lifestyle factors contribute to individual-level risk of coronary artery disease. The extent to which increased genetic risk can be offset by a healthy lifestyle is unknown.
Methods
Using a polygenic score of DNA sequence polymorphisms, we quantified genetic risk for coronary artery disease in three prospective cohorts — 7814 participants in the Atherosclerosis Risk in Communities (ARIC) study, 21,222 in the Women’s Genome Health Study (WGHS), and 22,389 in the Malmö Diet and Cancer Study (MDCS) — and in 4260 participants in the cross-sectional BioImage Study for whom genotype and covariate data were available. We also determined adherence to a healthy lifestyle among the participants using a scoring system consisting of four factors: no current smoking, no obesity, regular physical activity, and a healthy diet.
Results
The relative risk of incident coronary events was 91 …
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AV Khera, CA Emdin, I Drake, P Natarajan, AG Bick… - New England Journal of Medicine, 2016