作者
H Immo Lehmann, Daniel Richter, Hannah Prokesch, Christian Graeff, Matthias Prall, Palma Simoniello, Claudia Fournier, Julia Bauer, Robert Kaderka, Alexander Weymann, Gábor Szabó, Karin Sonnenberg, Anna M Constantinescu, Susan B Johnson, Juna Misiri, Mitsuru Takami, Robert C Miller, Michael G Herman, Samuel J Asirvatham, Stephan Brons, Oliver Jäkel, Thomas Haberer, Jürgen Debus, Marco Durante, Christoph Bert, Douglas L Packer
发表日期
2015/4
期刊
Circulation: Arrhythmia and Electrophysiology
卷号
8
期号
2
页码范围
429-438
出版商
Lippincott Williams & Wilkins
简介
Background
Particle therapy, with heavy ions such as carbon-12 (12C), delivered to arrhythmogenic locations of the heart could be a promising new means for catheter-free ablation. As a first investigation, we tested the feasibility of in vivo atrioventricular node ablation, in Langendorff-perfused porcine hearts, using a scanned 12C beam.
Methods and Results
Intact hearts were explanted from 4 (30–40 kg) pigs and were perfused in a Langendorff organ bath. Computed tomgraphic scans (1 mm voxel and slice spacing) were acquired and 12C ion beam treatment planning (optimal accelerator energies, beam positions, and particle numbers) for atrioventricular node ablation was conducted. Orthogonal x-rays with matching of 4 implanted clips were used for positioning. Ten Gray treatment plans were repeatedly administered, using pencil beam scanning. After delivery, positron emission tomography-computed …
学术搜索中的文章
HI Lehmann, D Richter, H Prokesch, C Graeff, M Prall… - Circulation: Arrhythmia and Electrophysiology, 2015