作者
Tekla Gj Van Rossum, Arnold G Vulto, Wim CJ Hop, Johannes T Brouwer, Hubert Gm Niesters, Solko W Schalm
发表日期
1999/11
期刊
Journal of gastroenterology and hepatology
卷号
14
期号
11
页码范围
1093-1099
出版商
Blackwell Science Pty
简介
Background : In Japan, glycyrrhizin therapy is widely used for chronic hepatitis C and reportedly reduces the progression of liver disease to hepatocellular carcinoma. The aims of this study were to evaluate the effect of glycyrrhizin on serum alanine aminotransferase (ALT), hepatitis C virus (HCV)‐RNA and its safety in European patients.
Methods : Fifty‐seven patients with chronic hepatitis C, non‐responders or unlikely to respond (genotype 1/cirrhosis) to interferon therapy, were randomized to one of the four dose groups: 240, 160 or 80 mg glycyrrhizin or placebo (0 mg glycyrrhizin). Medication was administered intravenously thrice weekly for 4 weeks; follow up also lasted for 4 weeks.
Results : Within 2 days of start of therapy, serum ALT had dropped 15% below baseline in the three dosage groups (P < 0.02). The mean ALT decrease at the end of active treatment was 26 …
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