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Objectives: This study sought to identify opportunities to safely turn off frequently overridden drug–drug interaction alerts (DDIs) in computerized physician order entry (CPOE).

Design: Quantitative retrospective analysis of drug safety alerts overridden during 1 month and qualitative interviews with 24 respondents (18 physicians and 6 pharmacists) about turning off frequently overridden DDI alerts, based on the Dutch drug database, in a hospital setting. Screen shots and complete texts of frequently overridden DDIs were presented to physicians of internal medicine, cardiology, and surgery and to hospital pharmacists who were asked whether these could be turned off hospital-wide without impairing patient safety, and the reasons for their recommendations.

Results: Data on the frequency of alerts overridden in 1 month identified 3,089 overrides, of which 1,963 were DDIs. The …