作者
Rajiv S Deshpande, Michael C Langham, Hyunyeol Lee, Nada Kamona, Felix W Wehrli
发表日期
2024/5
期刊
Magnetic Resonance in Medicine
卷号
91
期号
5
页码范围
2057-2073
简介
Purpose
Renal metabolic rate of oxygen (rMRO2) is a potentially important biomarker of kidney function. The key parameters for rMRO2 quantification include blood flow rate (BFR) and venous oxygen saturation (SvO2) in a draining vessel. Previous approaches to quantify renal metabolism have focused on the single organ. Here, both kidneys are considered as one unit to quantify bilateral rMRO2. A pulse sequence to facilitate bilateral rMRO2 quantification is introduced.
Methods
To quantify bilateral rMRO2, measurements of BFR and SvO2 are made along the inferior vena cava (IVC) at suprarenal and infrarenal locations. From the continuity equation, these four parameters can be related to derive an expression for bilateral rMRO2. The recently reported K‐MOTIVE pulse sequence was implemented at four locations: left kidney, right kidney, suprarenal IVC, and infrarenal IVC. A dual‐band variant of K‐MOTIVE …
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