作者
Paul M Schroder, Mithun Khattar, Caitlin E Baum, Yoshihiro Miyahara, Wenhao Chen, Rohit Vyas, Shravan Muralidharan, Beata Mierzejewska, Stanislaw M Stepkowski
发表日期
2015/6
期刊
Diabetologia
卷号
58
页码范围
1309-1318
出版商
Springer Berlin Heidelberg
简介
Aims/hypothesis
T cells play a major role in the pathogenesis of type 1 diabetes, and there is great interest in developing curative immunotherapies targeting these cells. In this study, a monoclonal antibody (mAb) targeting the T cell receptor β-chain (TCRβ) was investigated for its ability to prevent and reverse disease in mouse models of diabetes.
Methods
RIP-OVAhi (C57BL/6-Tg(Ins2-OVA)59Wehi/WehiJ) mice adoptively transferred with ovalbumin-specific T cells (an induced model of diabetes) and NOD mice (a spontaneous model of diabetes) were used to test anti-TCRβ mAb therapy as a means of preventing and reversing type 1 diabetes.
Results
A single dose of anti-TCRβ completely prevented disease in RIP-OVAhi mice without inducing the release of inflammatory cytokines. Transient anti-TCRβ therapy …
学术搜索中的文章
PM Schroder, M Khattar, CE Baum, Y Miyahara… - Diabetologia, 2015