作者
Tingfeng Xu, Liying Ren, Minjun Liao, Bigeng Zhao, Rongyu Wei, Zhipeng Zhou, Yong He, Hao Zhang, Dongbo Chen, Hongsong Chen, Weijia Liao
发表日期
2022/3/20
期刊
Journal of Hepatocellular Carcinoma
页码范围
189-201
出版商
Taylor & Francis
简介
Purpose
Microvascular invasion (MVI) impairs long-term prognosis of patients with hepatocellular carcinoma (HCC). We aimed to develop a novel nomogram to predict MVI and patients’ prognosis based on radiomic features of contrast-enhanced CT (CECT).
Patients and Methods
HCC patients who underwent curative resection were enrolled. The radiomic features were extracted from the region of tumor, and the optimal MVI-related radiomic features were selected and applied to construct radiomic signature (Rad-score). The prediction models were created according to the logistic regression and evaluated. Biomarkers were analyzed via q-PCR from randomly selected HCC patients. Correlations between biomarkers and radiomic signature were analyzed.
Results
A total of 421 HCC patients were enrolled. A total of 1962 radiomic features were extracted from the region of tumor, and the 11 optimal MVI-related …
学术搜索中的文章
T Xu, L Ren, M Liao, B Zhao, R Wei, Z Zhou, Y He… - Journal of Hepatocellular Carcinoma, 2022