作者
Robert C Culverhouse, Nancy L Saccone, Amy C Horton, Yinjiao Ma, Kaarin J Anstey, Tobias Banaschewski, Margit Burmeister, Sarah Cohen-Woods, Bruno Etain, Helen L Fisher, Noreen Goldman, Sébastien Guillaume, John Horwood, Gabriella Juhasz, Kathryn J Lester, Laura Mandelli, Christel M Middeldorp, Emilie Olié, Sandra Villafuerte, Tracy M Air, Ricardo Araya, Lucy Bowes, Richard Burns, Enda M Byrne, Carolyn Coffey, William L Coventry, KAB Gawronski, Dana Glei, Alex Hatzimanolis, Jouke-Jan Hottenga, Isabelle Jaussent, Catharine Jawahar, Christine Jennen-Steinmetz, John R Kramer, Mohamed Lajnef, Keriann Little, Henriette Meyer zu Schwabedissen, Matthias Nauck, Esther Nederhof, Peter Petschner, Wouter J Peyrot, Christian Schwahn, Grant Sinnamon, David Stacey, Yan Tian, Catherine Toben, Sandra Van der Auwera, Nick Wainwright, Jen-Chyong Wang, Gonneke Willemsen, Ian M Anderson, Volker Arolt, Cecilia Åslund, Gyorgy Bagdy, Bernhard T Baune, Frank Bellivier, Dorret I Boomsma, Philippe Courtet, Udo Dannlowski, Eco JC de Geus, John FW Deakin, Simon Easteal, Thalia Eley, David M Fergusson, Alison M Goate, Xenia Gonda, Hans J Grabe, Claudia Holzman, Eric O Johnson, Martin Kennedy, Manfred Laucht, Nicholas G Martin, Marcus R Munafò, Kent W Nilsson, Albertine J Oldehinkel, CA Olsson, Johan Ormel, Christian Otte, George C Patton, Brenda WJH Penninx, Karen Ritchie, Marco Sarchiapone, JM Scheid, Alessandro Serretti, Johannes H Smit, Nicholas C Stefanis, Paul G Surtees, Henry Völzke, Maxine Weinstein, Mary Whooley, John I Nurnberger Jr, Naomi Breslau, Laura J Bierut
发表日期
2018/1
期刊
Molecular psychiatry
卷号
23
期号
1
页码范围
133-142
出版商
Nature Publishing Group
简介
The hypothesis that the S allele of the 5-HTTLPR serotonin transporter promoter region is associated with increased risk of depression, but only in individuals exposed to stressful situations, has generated much interest, research and controversy since first proposed in 2003. Multiple meta-analyses combining results from heterogeneous analyses have not settled the issue. To determine the magnitude of the interaction and the conditions under which it might be observed, we performed new analyses on 31 data sets containing 38 802 European ancestry subjects genotyped for 5-HTTLPR and assessed for depression and childhood maltreatment or other stressful life events, and meta-analysed the results. Analyses targeted two stressors (narrow, broad) and two depression outcomes (current, lifetime). All groups that published on this topic prior to the initiation of our study and met the assessment and sample size …
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RC Culverhouse, NL Saccone, AC Horton, Y Ma… - Molecular psychiatry, 2018