作者
Emma Nilsson, Anna Benrick, Milana Kokosar, Anna Krook, Eva Lindgren, Thomas Källman, Mihaela M Martis, Kurt Højlund, Charlotte Ling, Elisabet Stener-Victorin
发表日期
2018/12
期刊
The Journal of Clinical Endocrinology & Metabolism
卷号
103
期号
12
页码范围
4465-4477
出版商
Endocrine Society
简介
Context
Insulin resistance in skeletal muscle is a major risk factor for the development of type 2 diabetes in women with polycystic ovary syndrome (PCOS). Despite this, the mechanisms underlying insulin resistance in PCOS are largely unknown.
Objective
To investigate the genome-wide DNA methylation and gene expression patterns in skeletal muscle from women with PCOS and controls and relate them to phenotypic variations.
Design/Participants
In a case-control study, skeletal muscle biopsies from women with PCOS (n = 17) and age-, weight-, and body mass index‒matched controls (n = 14) were analyzed by array-based DNA methylation and mRNA expression profiling.
Results
Eighty-five unique transcripts were differentially expressed in muscle from women with PCOS vs controls, including DYRK1A, SYNPO2, SCP2, and …
学术搜索中的文章
E Nilsson, A Benrick, M Kokosar, A Krook, E Lindgren… - The Journal of Clinical Endocrinology & Metabolism, 2018