作者
M Maliqueo, I Sundström Poromaa, E Vanky, R Fornes, A Benrick, Helena Åkerud, S Stridsklev, F Labrie, T Jansson, E Stener-Victorin
发表日期
2015/3/1
期刊
Human reproduction
卷号
30
期号
3
页码范围
692-700
出版商
Oxford University Press
简介
STUDY QUESTION
Does polycystic ovary syndrome (PCOS) in women without pregnancy complications affect placental signal transducer and activator of transcription 3 (STAT3) and mechanistic target of rapamycin (mTOR) signaling?
SUMMARY ANSWER
Placental STAT3 signaling is activated but mTOR signaling is unaffected in PCOS.
WHAT IS KNOWN ALREADY
Women with PCOS have increased risk of poor pregnancy outcomes (e.g. restricted or accelerated fetal growth), indicating placental dysfunction. Placental STAT3 and mTOR pathways regulate placental function and indirectly affect fetal growth.
STUDY DESIGN, SIZE, DURATION
In a case–control study, placental tissue and maternal blood were collected at delivery from 40 control pregnant women and 38 PCOS women with uncomplicated pregnancy …
学术搜索中的文章
M Maliqueo, I Sundström Poromaa, E Vanky, R Fornes… - Human reproduction, 2015