作者
Agustín F Fernández, Gustavo F Bayón, Rocío G Urdinguio, Estela G Toraño, María G García, Antonella Carella, Sandra Petrus-Reurer, Cecilia Ferrero, Pablo Martinez-Camblor, Isabel Cubillo, Javier García-Castro, Jesús Delgado-Calle, Flor M Pérez-Campo, José A Riancho, Clara Bueno, Pablo Menéndez, Anouk Mentink, Katia Mareschi, Fabian Claire, Corrado Fagnani, Emanuela Medda, Virgilia Toccaceli, Sonia Brescianini, Sebastián Moran, Manel Esteller, Alexandra Stolzing, Jan De Boer, Lorenza Nisticò, Maria A Stazi, Mario F Fraga
发表日期
2015/1/1
期刊
Genome research
卷号
25
期号
1
页码范围
27-40
出版商
Cold Spring Harbor Lab
简介
In differentiated cells, aging is associated with hypermethylation of DNA regions enriched in repressive histone post-translational modifications. However, the chromatin marks associated with changes in DNA methylation in adult stem cells during lifetime are still largely unknown. Here, DNA methylation profiling of mesenchymal stem cells (MSCs) obtained from individuals aged 2 to 92 yr identified 18,735 hypermethylated and 45,407 hypomethylated CpG sites associated with aging. As in differentiated cells, hypermethylated sequences were enriched in chromatin repressive marks. Most importantly, hypomethylated CpG sites were strongly enriched in the active chromatin mark H3K4me1 in stem and differentiated cells, suggesting this is a cell type–independent chromatin signature of DNA hypomethylation during aging. Analysis of scedasticity showed that interindividual variability of DNA methylation increased …
学术搜索中的文章
AF Fernández, GF Bayón, RG Urdinguio, EG Toraño… - Genome research, 2015
