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The majority of the people are exposed to hazardous paint fumes at some point in their lifetime either through their occupation, home, car refurbishing or through any contact. This current study examined the impact of automobile paint fumes on male abino wistar rats. Forty matured male Wistar rats weighing 180-300g were used for the study. The rats were divided into five group AE of eight rats per group. Group A served as control while Group BE served as the experimental animals. Group A received only feed and clean water for 14 days. Group BD were exposed to 40ml of Clear coat, Thinner and Hardener fume each via inhalation in addition to feed and water for 14 days. Group E: CTH (Clear+ thinner+ hardener)-exposed groups were exposed to 13.5 ml of Clear coat+ 13.5 ml of thinner and 1 3.3 ml of Hardener fume via inhalation in addition to feeding and water for the 14 days. At the end of two-weeks experiment, animals were sacrificed by cervical dislocation. Blood and heart tissues were harvested and used for biochemical and histopathological study. Exposure to car paint fumes caused cardiac damage evidenced by significant alteration in cardiac activity (Troponin-I, CK-MB, AST, LDH), lipid profile (HDL, LDL, CHOL, TAG) and antioxidant status (SOD, CAT, GSH, MDA, NO, XO) as compared to control rats. The results of these findings thus inferred that exposure to paint fume may be toxic to the heart.