作者
Kathryn H Myburgh, Maria J Kruger, Carine Smith
发表日期
2012/9/1
期刊
The Journal of nutritional biochemistry
卷号
23
期号
9
页码范围
1072-1079
出版商
Elsevier
简介
Acute skeletal muscle damage results in fiber disruption, oxidative stress and inflammation. We investigated cell-specific contributions to the regeneration process after contusion-induced damage (rat gastrocnemius muscle) with or without chronic grape seed-derived proanthocyanidolic oligomer (PCO) administration. In this placebo-controlled study, male Wistar rats were subjected to PCO administration for 2 weeks, after which they were subjected to a standardised contusion injury. Supplementation was continued after injury. Immune and satellite cell responses were assessed, as well as oxygen radical absorption capacity and muscle regeneration. PCO administration resulted in a rapid satellite cell response with an earlier peak in activation (Pax7+, CD56+, at 4 h post-contusion) vs. placebo groups (PLA) (P<.001: CD56+ on Day 5 and Pax7+ on Day 7). Specific immune-cell responses in PLA followed expected …
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KH Myburgh, MJ Kruger, C Smith - The Journal of nutritional biochemistry, 2012