作者
Genevieve Nadeau, Judith Bellemare, Étienne Audet-Walsh, Christine Flageole, Shu-Pin Huang, Bo-Ying Bao, Pierre Douville, Patrick Caron, Yves Fradet, Louis Lacombe, Chantal Guillemette, Eric Levesque
发表日期
2011/9/1
期刊
The Journal of Clinical Endocrinology & Metabolism
卷号
96
期号
9
页码范围
E1550-E1557
出版商
Oxford University Press
简介
Context
The prognostic relevance of inherited variations in hormone-related genes in the context of prostate cancer (PCa) progression has not been well studied. Of these, UDP-glucuronosyltransferase (UGT) gene products lead to inactivation of steroids.
Objective
Our objective was to determine whether polymorphisms in five UGT genes, involved in steroid metabolism, are associated with the risk of biochemical recurrence after radical prostatectomy (RP) and to examine their relationship with hormonal exposure.
Design
The study included 526 Caucasian and 320 Asian men who underwent RP for clinically localized PCa. The relationship between genotypes and biochemical recurrence were assessed with multivariate Cox proportional hazard models. Plasma steroids were measured using specific and sensitive mass spectrometry-based methods …
学术搜索中的文章
G Nadeau, J Bellemare, É Audet-Walsh, C Flageole… - The Journal of Clinical Endocrinology & Metabolism, 2011