作者
Ji Wang, Hui-Jiuan Chen, Tian Hang, Yang Yu, Guishi Liu, Gen He, Shuai Xiao, Bo-ru Yang, Chengduan Yang, Fanmao Liu, Jun Tao, Mei X Wu, Xi Xie
发表日期
2018/11
期刊
Nature nanotechnology
卷号
13
期号
11
页码范围
1078-1086
出版商
Nature Publishing Group UK
简介
Microbial biochemicals have been indicated as the primary stimulators of innate immunity, the first line of the body’s defence against infections. However, the influence of topological features on a microbe’s surface on immune responses remains largely unknown. Here we demonstrate the ability of TiO2 microparticles decorated with nanospikes (spiky particles) to activate and amplify the immune response in vitro and in vivo. The nanospikes exert mechanical stress on the cells, which results in potassium efflux and inflammasome activation in macrophages and dendritic cells during phagocytosis. The spiky particles augment antigen-specific humoral and cellular immune responses in the presence of monophosphoryl lipid A and elicit protective immunity against tumour growth and influenza viral infection. The study offers insights into how surface physical cues can tune the activation of innate immunity and provides …
学术搜索中的文章
J Wang, HJ Chen, T Hang, Y Yu, G Liu, G He, S Xiao… - Nature nanotechnology, 2018