作者
Xiaoyan Lu, Zheng-Yi Zhou, Yiqiao Xin, Min-Jung Wang, Emma Gray, Vipul Jairath, James Oliver Lindsay
发表日期
2024/1/1
期刊
Inflammatory Bowel Diseases
卷号
30
期号
1
页码范围
64-77
出版商
Oxford University Press
简介
Background
Where head-to-head trials are lacking, indirect comparative effectiveness can aid treatment decisions. We conducted matching-adjusted indirect comparisons of clinical outcomes with filgotinib vs recently approved comparators (vedolizumab, tofacitinib, ustekinumab) in patients with moderately to severely active ulcerative colitis (UC).
Methods
Individual patient data from the SELECTION trial (NCT02914522) for filgotinib 200 mg were weighted to match average baseline characteristics of active treatment and placebo arms in comparator trials. Efficacy outcomes were compared for biologic-naive and biologic-experienced subgroups in induction and maintenance populations, if data were available. Safety and health-related quality of life outcomes were compared in the overall maintenance population.
Results
Filgotinib had a similar effect on …
学术搜索中的文章
X Lu, ZY Zhou, Y Xin, MJ Wang, E Gray, V Jairath… - Inflammatory Bowel Diseases, 2024