作者
X Lu, E Gray, Y Xin, J Zhou, V Jairath, JO Lindsay
发表日期
2022/7/1
期刊
Value in Health
卷号
25
期号
7
页码范围
S321
出版商
Elsevier
简介
Objectives
In the absence of head-to-head trials, matching-adjusted indirect comparisons (MAIC) was conducted to compare efficacy and safety of filgotinib vs. tofacitinib in patients with moderately to severely active ulcerative colitis (UC) after adjusting for cross-trial differences.
Methods
Individual patient data (IPD) from SELECTION for filgotinib 200mg and published aggregate data for tofacitinib from OCTAVE 1&2 (induction) and OCTAVE SUSTAIN (maintenance) were used. SELECTION IPD were weighted to match average baseline characteristics in OCTAVE for the active treatment and placebo arms, including sex, age, weight, smoking status, total Mayo score, UC duration, history of biologic failure, and concomitant corticosteroid use. Efficacy outcomes were compared separately for biologic-naïve and biologic-experienced subgroups in both induction and maintenance phases. Safety outcomes were compared …
学术搜索中的文章
X Lu, E Gray, Y Xin, J Zhou, V Jairath, JO Lindsay - Value in Health, 2022