作者
Bhanu Prakash Kolla, Meghna Prabhdas Mansukhani, Terry Schneekloth
发表日期
2011/9/1
来源
Alcohol and Alcoholism
卷号
46
期号
5
页码范围
578-585
出版商
Oxford University Press
简介
Aims: To conduct a systematic review of pharmacological agents used to treat sleep problems in alcohol recovery. Methods: In accordance with the Quorum statement, we searched PubMed, EMBASE, Psych Info and Medline databases using the terms alcohol, insomnia/sleep and treatment/management with no year/language restrictions. Results: The search revealed 1239 articles and 20 met inclusion criteria. Trazodone was compared against placebo and found to be superior in two trials. Trazodone and gabapentin improved sleep measures with gabapentin performing significantly better in an open-label study. The data regarding gabapentin are equivocal with few studies showing a clear benefit. In one randomized trial, topiramate resulted in improved subjective sleep measures and a reduction in the percentage of heavy drinking days. Two randomized control trials of carbamazepine revealed …
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