作者
Meghna P Mansukhani, Shihan Wang, Virend K Somers
发表日期
2015/2/1
来源
Experimental physiology
卷号
100
期号
2
页码范围
130-135
简介
New Findings
- What is the topic of this review?This review summarizes chemoreflex physiology in health and disease, with specific focus on chemoreflex‐mediated pathophysiology in obstructive and central sleep apnoea.
- What advances does it highlight?Chemoreflex mechanisms are thought to contribute significantly to the pathophysiology and adverse outcomes seen in sleep apnoea. Clinical implications of altered chemoreflex function in sleep apnoea from recent studies in humans, including cardiac arrhythmias, coronary artery disease, systolic/diastolic heart failure and sudden cardiac death are highlighted.
Activation of the chemoreflex in response to hypoxaemia results in an increase in sympathetic neural outflow. This process is predominantly mediated by the peripheral chemoreceptors in the carotid bodies and is potentiated by the absence of the sympatho‐inhibitory influence of ventilation during …
学术搜索中的文章
MP Mansukhani, S Wang, VK Somers - Experimental physiology, 2015