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Glioblastoma Multiforme (GBM) is among the most devastating cancers, with a median survival of approximately 1 year. 1 GBM presents unique challenges to therapy due to its location, aggressive biological behavior and diffuse infiltrative growth. Despite the development of new surgical and radiation techniques and the use of multiple antineoplastic drugs, a cure for malignant gliomas remains elusive. 2 The scarce efficacy of current treatments reflects the resistance of glioblastoma cells to cytotoxic agents in vitro. 3, 4 Moreover, the short interval for tumor recurrence in glioblastoma patients suggests that tumorigenic cells are able to overtake the treatments without major damage. The cancer stem cell hypothesis asserts that solid tumors are maintained exclusively by a rare fraction of cancer cells with stem cell properties. The existence of cancer stem cells was first proven in the context of acute myeloid leukemia. 5 …