作者
Haotian Li, Guohui Yan, Wanrong Luo, Tingting Liu, Yan Wang, Ruibin Liu, Weihao Zheng, Yi Zhang, Kui Li, Li Zhao, Catherine Limperopoulos, Yu Zou, Dan Wu
发表日期
2021/7
期刊
Brain Structure and Function
卷号
226
期号
6
页码范围
1961-1972
出版商
Springer Berlin Heidelberg
简介
Fetal brain MRI has become an important tool for in utero assessment of brain development and disorders. However, quantitative analysis of fetal brain MRI remains difficult, partially due to the limited tools for automated preprocessing and the lack of normative brain templates. In this paper, we proposed an automated pipeline for fetal brain extraction, super-resolution reconstruction, and fetal brain atlasing to quantitatively map in utero fetal brain development during mid-to-late gestation in a Chinese population. First, we designed a U-net convolutional neural network for automated fetal brain extraction, which achieved an average accuracy of 97%. We then generated a developing fetal brain atlas, using an iterative linear and nonlinear registration approach. Based on the 4D spatiotemporal atlas, we quantified the morphological development of the fetal brain between 23 and 36 weeks of gestation. The proposed …
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H Li, G Yan, W Luo, T Liu, Y Wang, R Liu, W Zheng… - Brain Structure and Function, 2021