作者
C Marcela Diaz-Montero, Yong Wang, Lijian Shao, Wei Feng, Abdel-Aziz Zidan, Christopher J Pazoles, Alberto J Montero, Daohong Zhou
发表日期
2012/5/1
期刊
Free Radical Biology and Medicine
卷号
52
期号
9
页码范围
1560-1568
出版商
Pergamon
简介
The oxidized glutathione mimetic NOV-002 is a unique anti-tumor agent that not only has the ability to inhibit tumor cell proliferation, survival, and invasion, but in some settings can also ameliorate cytotoxic chemotherapy-induced hematopoietic and immune suppression. However, the mechanisms by which NOV-002 protects the hematopoietic and immune systems against the cytotoxic effects of chemotherapy are not known. Therefore, in this study we investigated the mechanisms of action of NOV-002 using a mouse model in which hematopoietic and immune suppression was induced by cyclophosphamide (CTX) treatment. We found that NOV-002 treatment in a clinically comparable dose regimen attenuated CTX-induced reduction in bone marrow hematopoietic stem and progenitor cells (HSPCs) and reversed the immunosuppressive activity of myeloid-derived suppressor cells (MDSCs), which led to a …
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CM Diaz-Montero, Y Wang, L Shao, W Feng, AA Zidan… - Free Radical Biology and Medicine, 2012