作者
Martin Ugander, Paul S Bagi, Abiola J Oki, Billy Chen, Li-Yueh Hsu, Anthony H Aletras, Saurabh Shah, Andreas Greiser, Peter Kellman, Andrew E Arai
发表日期
2012/6
期刊
JACC: Cardiovascular Imaging
卷号
5
期号
6
页码范围
596-603
出版商
American College of Cardiology Foundation
简介
Objectives
The aim of this study was to determine whether cardiac magnetic resonance (CMR) in vivo T1 mapping can measure myocardial area at risk (AAR) compared with microspheres or T2 mapping CMR.
Background
If T2-weighted CMR is abnormal in the AAR due to edema related to myocardial ischemia, then T1-weighted CMR should also be able to detect and accurately quantify AAR.
Methods
Dogs (n = 9) underwent a 2-h coronary occlusion followed by 4 h of reperfusion. CMR of the left ventricle was performed for mapping of T1 and T2 prior to any contrast administration. AAR was defined as regions that had a T1 or T2 value (ms) >2 SD from remote myocardium, and regions with microsphere blood flow (ml/min/g) during occlusion <2 SD from remote myocardium. Infarct size was determined by triphenyltetrazolium chloride staining.
Results
The relaxation parameters T1 and T2 were increased in the AAR …
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M Ugander, PS Bagi, AJ Oki, B Chen, LY Hsu… - JACC: Cardiovascular Imaging, 2012