作者
Catarina Vizetto-Duarte, Pedro Castelo-Branco, Luísa Custódio
发表日期
2021/7/1
来源
Current medicinal chemistry
卷号
28
期号
22
页码范围
4343-4355
出版商
Bentham Science Publishers
简介
Cancer is the world’s leading cause of death after heart diseases and involves abnormal cell growth at a primary site and the potential to spread to other parts of the body. Tumors are highly heterogeneous and consist of subgroups of cells with distinct characteristics. Of these, the cancer stem cells (CSC) niche plays a crucial role in driving the spread of the tumor and are thought to provide treatment resistance. CSC is a rare special population of cancer cells exhibiting high tumorigenic properties together with self-renewal and differentiation capability. CSC is not only linked with high tumor-initiating activity, but is also implicated in chemotherapeutic resistance, metastasis, epithelial to mesenchymal transition, and recurrence. Thereafter, novel therapeutic strategies targeting CSC are in need to improve long-term clinical outcomes. The literature supports the evidence that marine natural compounds can exhibit …
学术搜索中的文章
C Vizetto-Duarte, P Castelo-Branco, L Custódio - Current medicinal chemistry, 2021