作者
Jennifer Cautela, Franck Rouby, Joe-Elie Salem, Joachim Alexandre, Ugo Scemama, Charles Dolladille, Ariel Cohen, Franck Paganelli, Stéphane Ederhy, Franck Thuny
发表日期
2020/4/1
期刊
Canadian Journal of Cardiology
卷号
36
期号
4
页码范围
476-481
出版商
Elsevier
简介
Isolated cases of acute coronary syndrome (ACS) associated with immune checkpoint inhibitors (ICIs) have been described without the establishment of a formal cause-and-effect relationship between treatment and adverse event. We reported a case of ACS after the first administration of an ICI and with a fatal recurrence in another coronary area immediately after readministration. According to guidelines, causality was considered to be certain. Subsequently, we queried the French pharmacovigilance database and found 4 cases of ACS with coronary artery thrombosis. Causality was probable in those patients. These data suggest that ACS may be another life-threatening cardiac adverse event occurring with ICI exposure.
学术搜索中的文章
J Cautela, F Rouby, JE Salem, J Alexandre… - Canadian Journal of Cardiology, 2020