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WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT

• Dopamine agonists used in Parkinson's disease patients are associated with excessive daytime sleepiness and sleep attacks occurring without prior warning.

• Parkinson's disease accounts in itself for a variety of sleep disorders. It is therefore important to study the drug‐induced sleepiness in healthy volunteers.

• In healthy subjects, pramipexole has proved to decrease alertness and ropinirole to reduce sleep latency.

WHAT THIS STUDY ADDS

• Results from our study show that pramipexole reduces the mean sleep latency as measured by the Multiple Sleep Latency Test in healthy volunteers, hence providing an objective measure of increased sleepiness.

• Furthermore, the reduction in sleep latency was not associated with a subjective impression of increased sleepiness.

• Such dissociation may underlie the occurrence of sleep attacks without …