作者
Ludovic Reveiz, Xavier Bonfill, Demian Glujovsky, Carlos E Pinzon, Claudia Asenjo-Lobos, Marcela Cortes, Martin Canon, Ariel Bardach, Daniel Comandé, Andrés F Cardona
发表日期
2012/5/1
期刊
Journal of clinical epidemiology
卷号
65
期号
5
页码范围
482-487
出版商
Pergamon
简介
OBJECTIVE
To determine the prevalence of trial registration in randomized controlled trials (RCTs) published in 2010 (PUBMED/LILACS) from Latin America and the Caribbean’s (LAC) and to compare methodological characteristics between registered and nonregistered RCTs.
STUDY DESIGN AND SETTING
A search for detecting RCTs in which at least the first/contact author had a LAC’s affiliation was made. We determined if RCTs were registered in the International Clinical Trial Registry Platform (ICTRP). Data were independently extracted by two authors. The risk of bias (RoB) was assessed in all registered RCTs (n=89) and in a sample of nonregistered RCTs (n=237).
RESULTS
The search identified 1,695 references; 526 RCTs from 19 countries were included. 16.9% (89/526) of RCTs were registered in the ICTRP; however, only 21 (4.0%) were prospectively registered. A significant difference was found in …
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