作者
Agustín Ciapponi, Mabel Berrueta, Edward PK Parker, Ariel Bardach, Agustina Mazzoni, Steven A Anderson, Fernando J Argento, Jamile Ballivian, Karin Bok, Daniel Comandé, Erin Goucher, Beate Kampmann, Flor M Munoz, Federico Rodriguez Cairoli, Victoria Santa María, Andy S Stergachis, Gerald Voss, Xu Xiong, Natalia Zamora, Sabra Zaraa, Pierre M Buekens
发表日期
2023/6/7
来源
Vaccine
卷号
41
期号
25
页码范围
3688-3700
出版商
Elsevier
简介
Background
Assessment of COVID-19 vaccines safety during pregnancy is urgently needed.
Methods
We conducted a systematic review and meta-analysis to evaluate the safety of COVID-19 vaccines, including their components and technological platforms used in other vaccines during pregnancy and animal studies to complement direct evidence. We searched literature databases from its inception to September 2021 without language restriction, COVID-19 vaccine websites, and reference lists of other systematic reviews and the included studies. Pairs of reviewers independently selected, data extracted, and assessed the risk of bias of the studies. Discrepancies were resolved by consensus. (PROSPERO CRD42021234185).
Results
We retrieved 8,837 records from the literature search; 71 studies were included, involving 17,719,495 pregnant persons and 389 pregnant animals. Most studies (94%) were …
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