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The use of machine learning techniques for early diseases diagnosis has attracted the attention of scholars worldwide. Parkinson’s Disease (PD) is one of the most common neurological and complicated diseases affecting the central nervous system. Unified Parkinson’s Disease Rating Scale (UPDRS) is widely used for tracking PD symptom progression. Motor- and Total-UPDRS are two important clinical scales of PD. The aim of this study is to predict UPDRS scores through analyzing the speech signal properties which is important in PD diagnosis. We take the advantages of ensemble learning and dimensionality reduction techniques and develop a new hybrid method to predict Total- and Motor-UPDRS. We accordingly improve the time complexity and accuracy of the PD diagnosis systems, respectively, by using Singular Value Decomposition (SVD) and ensembles of Adaptive Neuro-Fuzzy Inference System …