作者
Christopher C Cheung, Zachary WM Laksman, Gregory Mellor, Shubhayan Sanatani, Andrew D Krahn
发表日期
2016/4/1
来源
Canadian Journal of Cardiology
卷号
32
期号
4
页码范围
452-458
出版商
Elsevier
简介
Sudden cardiac death (SCD) in an apparently healthy individual is a tragedy that prompts a series of investigations to identify the cause of death and to prevent SCD in potentially at-risk family members. Several inherited channelopathies and cardiomyopathies, including long QT syndrome (LQTS), catecholaminergic polymorphic ventricular cardiomyopathy (CPVT), hypertrophic cardiomyopathy (HCM), and arrhythmogenic right ventricular cardiomyopathy (ARVC) are associated with exercise-related SCD. Exercise restriction has been a historical mainstay of therapy for these conditions. Syncope and cardiac arrest occur during exercise in LQTS and CPVT because of ventricular arrhythmias, which are managed with β-blockade and exercise restriction. Exercise may provoke hemodynamic or ischemic changes in HCM, leading to ventricular arrhythmias. ARVC is a disease of the desmosome, whose underlying …
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CC Cheung, ZWM Laksman, G Mellor, S Sanatani… - Canadian Journal of Cardiology, 2016