作者
Miguel Ruiz-Canela, Marta Guasch-Ferré, Estefanía Toledo, Clary B Clish, Cristina Razquin, Liming Liang, Dong D Wang, Dolores Corella, Ramón Estruch, Álvaro Hernáez, Edward Yu, Enrique Gómez-Gracia, Yan Zheng, Fernando Arós, Dora Romaguera, Courtney Dennis, Emilio Ros, José Lapetra, Lluis Serra-Majem, Christopher Papandreou, Olga Portoles, Montserrat Fitó, Jordi Salas-Salvadó, Frank B Hu, Miguel A Martínez-González
发表日期
2018/7
期刊
Diabetologia
卷号
61
页码范围
1560-1571
出版商
Springer Berlin Heidelberg
简介
Aims/hypothesis
Branched-chain amino acids (BCAAs) and aromatic amino acids (AAAs) are associated with type 2 diabetes. However, repeated measurements of BCAA/AAA and their interactions with dietary interventions have not been evaluated. We investigated the associations between baseline and changes at 1 year in BCAA/AAA with type 2 diabetes in the context of a Mediterranean diet (MedDiet) trial.
Methods
We included 251 participants with incident type 2 diabetes and a random sample of 694 participants (641 participants without type 2 diabetes and 53 overlapping cases) in a case-cohort study nested within the PREvención con DIeta MEDiterránea (PREDIMED) trial. Participants were randomised to a MedDiet+extra-virgin olive oil (n = 273), a MedDiet+nuts (n = 324) or a control diet (n = 295). We used LC-MS/MS to measure plasma …
学术搜索中的文章
M Ruiz-Canela, M Guasch-Ferré, E Toledo, CB Clish… - Diabetologia, 2018