作者
Wenjie Xia, Piyapong Simtong, Sentot Santoso
发表日期
2017/2
来源
ISBT Science Series
卷号
12
期号
1
页码范围
62-67
简介
Neutrophils are dynamic, motile cells that provide the first line of defence against many pathogens. Therefore, neutrophils are equipped with a number of receptors. Some of these receptors are known polymorphic carrying immunogenic structures. Immunization against these antigenic structures, known as human neutrophil antigen (HNA), can lead to the production of antibodies. These antibodies are implicated in a number of clinical conditions including immune‐mediated neutropenia, refractoriness to granulocyte transfusions and transfusion‐related acute lung injury. Based on the development of molecular genotyping, intensive studies on the allelic distribution of HNAs have been conducted all over the world. Significant disparity on the allelic distribution was observed, indicating different clinical relevance and priority of HNAs in different ethnic groups. Currently, except in Caucasians, only limited studies on the …
引用总数
201720182019202020211211
学术搜索中的文章