作者
Peter Lange, Bartolome Celli, Alvar Agustí, Gorm Boje Jensen, Miguel Divo, Rosa Faner, Stefano Guerra, Jacob Louis Marott, Fernando D Martinez, Pablo Martinez-Camblor, Paula Meek, Caroline A Owen, Hans Petersen, Victor Pinto-Plata, Peter Schnohr, Akshay Sood, Joan B Soriano, Yohannes Tesfaigzi, Jørgen Vestbo
发表日期
2015/7/9
期刊
New England Journal of Medicine
卷号
373
期号
2
页码范围
111-122
出版商
Massachusetts Medical Society
简介
Background
Chronic obstructive pulmonary disease (COPD) is thought to result from an accelerated decline in forced expiratory volume in 1 second (FEV1) over time. Yet it is possible that a normal decline in FEV1 could also lead to COPD in persons whose maximally attained FEV1 is less than population norms.
Methods
We stratified participants in three independent cohorts (the Framingham Offspring Cohort, the Copenhagen City Heart Study, and the Lovelace Smokers Cohort) according to lung function (FEV1 ≥80% or <80% of the predicted value) at cohort inception (mean age of patients, approximately 40 years) and the presence or absence of COPD at the last study visit. We then determined the rate of decline in FEV1 over time among the participants according to their FEV1 at cohort inception and COPD status at study end.
Results
Among 657 persons who had an FEV1 of less than 80% of the predicted …
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P Lange, B Celli, A Agustí, G Boje Jensen, M Divo… - New England Journal of Medicine, 2015