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Effects of Oxytetraxycline (OTC) and Furasol (FRS) on the growth performance and stomach wall lining of Clarias gariepinus were investigated over a period of 10 weeks. The control group (CTR) was fed with Diet 1 which contained no treatment while antibiotics were mixed with 100 g of commercial feed at the concentrations of 0.20% OTC (Diet 2), 0.4% OTC (Diet 3), 0.15% FRS (Diet 4), and 0.3% FRS (Diet 5). Fish were fed to satiation twice daily (0830 and 1600 h) while their water was changed every other day. With the exception of fish fed Diets 3 and 4, there was no significant difference (p> 0.05) in the average weight gain (AWG) and specific growth rate (SGR) in treated fish compared with CTR. At 0.20 and 0.40% OTC, SGR of fish were 2.59±0.03 and 2.1±0.21 respectively while at 0.15 and 0.30% FRS, SGR of fish were 1.67±0.07 and 2.57±0.06 respectively. Average feed intake (AFI) and feed conversion ratio (FCR) were not significantly difference (p> 0.05) between the CTR group and other experimental fish with the exception of fish fed diet 4. The best (0.73±0.07) and least (1.35±0.10) performances for FCR were recorded in fish fed diets 4 and 1 respectively. Severe impairments were observed on the stomach lining at 0.40% OTC and 0.30% FRS compared with mild impairments that were recorded at 0.20% OTC and 0.15% FRS inclusion levels. Implications of these findings are discussed.