作者
and The DCCT/EDIC Research Group Gubitosi-Klug RA, Braffett BH, White N, Sherwin RS, Service JF, Lachin JM, Tamborlane WV
发表日期
2017
期刊
Diabetes Care
卷号
40
页码范围
1010-16
简介
OBJECTIVE
During the Diabetes Control and Complications Trial (DCCT), intensive diabetes therapy achieving a mean HbA1c of ∼7% was associated with a threefold increase in the rate of severe hypoglycemia (defined as requiring assistance) compared with conventional diabetes therapy with a mean HbA1c of 9% (61.2 vs. 18.7 per 100 patient-years). After ∼30 years of follow-up, we investigated the rates of severe hypoglycemia in the DCCT/Epidemiology of Diabetes Inverventions and Complications (EDIC) cohort.
RESEARCH DESIGN AND METHODS
Rates of severe hypoglycemia were reported quarterly during DCCT and annually during EDIC (i.e., patient recall of episodes in the preceding 3 months). Risk factors influencing the rate of severe hypoglycemia over time were investigated.
RESULTS
One-half of the DCCT/EDIC cohort reported episodes of …
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