作者
and The DCCT/EDIC Research Group Purnell JQ, Braffett BH, Zinman B, Gubitosi-Klug RA, Sivitz W, Bantle JP, Ziegler G, Cleary PA, Brunzell JD
发表日期
2017
期刊
Diabetes Care
卷号
40
页码范围
1756-62
简介
OBJECTIVE
Intensive treatment (INT) of type 1 diabetes reduces the incidence of cardiovascular disease (CVD) events compared with conventional treatment (CONV), but it also results in more weight gain. Our objective was to examine whether excessive weight gain from INT of type 1 diabetes is independently associated with subsequent CVD events.
RESEARCH DESIGN AND METHODS
Quartiles (Q) of weight gain in 1,213 participants aged 18 years and older at enrollment in the Diabetes Control and Complications Trial (DCCT) were determined within randomized treatment groups (INT vs. CONV) using change in BMI from baseline to the closeout DCCT visits. Effects of this weight gain on CVD risk factors and outcomes during an additional 20 years of observational follow-up were then determined.
RESULTS
The Q4 INT group experienced greater …
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JQ Purnell, BH Braffett, B Zinman, RA Gubitosi-Klug… - Diabetes care, 2017