作者
and the DCCT/EDIC Research Group Rubin MR, de Boer IH, Backlund JYC, Arends V, Gubitosi-Klug R, Wallia A, Sinha Gregory N, Barnie A, Burghardt A, Lachin JM, Braffett BH, Schwartz A
发表日期
2022/6/1
期刊
J Clin Endocrinol Metab
卷号
107
期号
6
页码范围
e2405-e2416
出版商
Oxford University Press
简介
Context
Type 1 diabetes (T1D) is characterized by high fracture risk, yet little is known regarding diabetes-related mechanisms or risk factors.
Objective
Determine whether glycemic control, advanced glycation end products (AGEs), and microvascular complications are associated with bone turnover markers among older T1D adults.
Design
Cross-sectional.
Setting
Epidemiology of Diabetes Interventions and Complications study (6 of 27 clinical centers).
Participants
232 T1D participants followed for >30 years.
Exposures
Glycemic control ascertained as concurrent and cumulative hemoglobin A1c (HbA1c); kidney function, by estimated glomerular filtration rates (eGFR); and AGEs, by skin intrinsic fluorescence.
Main Outcome Measures
Serum procollagen 1 intact N-terminal …
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MR Rubin, IH De Boer, JYC Backlund, V Arends… - The Journal of Clinical Endocrinology & Metabolism, 2022
