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Objectives: Due to the effect of neurogenesis on memory and learning, in this study, we investigated the effects of MDMA on NeuN expression (a marker of neurogenesis) in the hippocampus.

Methods: Adult male Wistar rats (weighing 200-250 g) received a single intraperitoneal dose of 10 mg/kg of MDMA or were left undisrupted. The expression of NeuN was assessed using the immunohistochemistry method 7, 14, 28, and 60 days following MDMA administration.

Results: Our results showed that MDMA administration caused a decrease in NeuN expression in the experimental group compared with the control group.

Conclusions: These results suggest a negative correlation between MDMA administration and adult hippocampal neurogenesis.

Keywords: Ecstasy, NeuN, Hippocampus, Rat