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Methods: Adult Wistar male rats in the current study were treated with intrahippocampal Aβ as well as intraperitoneal callistephin injection. The day after the last administration, neuro D expression was assessed using an immunohistochemistry method. Finally, data were analyze d with SPSS using the one-way ANOVA test.

Results: Results of the current study showed that Aβ significantly decreased the expression of neuroD and callistephin could attenuate these changes.

Conclusion: In conclusion, results of the study suggested that callistephin can improve Aβinduced neurogenesis changes in rats.