作者
Annapaola Prestia, Anna Caroli, Sara K Wade, Wiesjie M Van Der Flier, Rik Ossenkoppele, Bart Van Berckel, Frederik Barkhof, Charlotte E Teunissen, Anders Wall, Stephen F Carter, Michael Schöll, Il Han Choo, Agneta Nordberg, Philip Scheltens, Giovanni B Frisoni
发表日期
2015/10/1
期刊
Alzheimer's & Dementia
卷号
11
期号
10
页码范围
1191-1201
出版商
Elsevier
简介
Introduction
Proposed diagnostic criteria (international working group and National Institute on Aging and Alzheimer's Association) for Alzheimer's disease (AD) include markers of amyloidosis (abnormal cerebrospinal fluid [CSF] amyloid beta [Aβ]42) and neurodegeneration (hippocampal atrophy, temporo-parietal hypometabolism on [18F]-fluorodeoxyglucose-positron emission tomography (FDG-PET), and abnormal CSF tau). We aim to compare the accuracy of these biomarkers, individually and in combination, in predicting AD among mild cognitive impairment (MCI) patients.
Methods
In 73 MCI patients, followed to ascertain AD progression, markers were measured. Sensitivity and specificity, positive (LR+) and negative (LR−) likelihood ratios, and crude and adjusted hazard ratios were computed.
Results
Twenty-nine MCI patients progressed and 44 remained stable. Positivity to any marker achieved the lowest LR …
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A Prestia, A Caroli, SK Wade, WM van der Flier… - Alzheimer's & Dementia, 2015