作者
Marissa D Zwan, Juha O Rinne, Steen G Hasselbalch, Agneta Nordberg, Alberto Lleó, Sanna-Kaisa Herukka, Hilkka Soininen, Ian Law, Justyna MC Bahl, Stephen F Carter, Juan Fortea, Rafael Blesa, Charlotte E Teunissen, Femke H Bouwman, Bart NM van Berckel, Pieter J Visser
发表日期
2016/1/5
期刊
Neurology
卷号
86
期号
1
页码范围
50-58
出版商
Lippincott Williams & Wilkins
简介
Objectives
To define CSF β-amyloid 1–42 (Aβ42) cutpoints to detect cortical amyloid deposition as assessed by 11C-Pittsburgh compound B ([11C]PiB)-PET and to compare these calculated cutpoints with cutpoints currently used in clinical practice.
Methods
We included 433 participants (57 controls, 99 with mild cognitive impairment, 195 with Alzheimer disease [AD] dementia, and 82 with non-AD dementia) from 5 European centers. We calculated for each center and for the pooled cohort CSF Aβ42 and Aβ42/tau ratio cutpoints for cortical amyloid deposition based on visual interpretation of [11C]PiB-PET images.
Results
Amyloid-PET–based calculated CSF Aβ42 cutpoints ranged from 521 to 616 pg/mL, whereas existing clinical-based cutpoints ranged from 400 to 550 pg/mL. Using the calculated cutpoint from the pooled sample (557 pg/mL), concordance between CSF Aβ42 and amyloid-PET was 84%. Similar …
学术搜索中的文章
MD Zwan, JO Rinne, SG Hasselbalch, A Nordberg… - Neurology, 2016