作者
Bruna Bellaver, João Pedro Ferrari-Souza, Lucas Uglione da Ros, Stephen F Carter, Elena Rodriguez-Vieitez, Agneta Nordberg, Luc Pellerin, Pedro Rosa-Neto, Douglas Teixeira Leffa, Eduardo R Zimmer
发表日期
2021/6/15
来源
Neurology
卷号
96
期号
24
页码范围
e2944-e2955
出版商
Lippincott Williams & Wilkins
简介
Objective
To perform a systematic review and meta-analysis to determine whether fluid and imaging astrocyte biomarkers are altered in Alzheimer disease (AD).
Methods
PubMed and Web of Science databases were searched for articles reporting fluid or imaging astrocyte biomarkers in AD. Pooled effect sizes were determined with standardized mean differences (SMDs) using the Hedge G method with random effects to determine biomarker performance. Adapted questions from the Quality Assessment of Diagnostic Accuracy Studies were applied for quality assessment. A protocol for this study has been previously registered in PROSPERO (registration number: CRD42020192304).
Results
The initial search identified 1,425 articles. After exclusion criteria were applied, 33 articles (a total of 3,204 individuals) measuring levels of glial fibrillary acidic protein (GFAP), S100B, chitinase-3-like protein 1 (YKL-40), and …
学术搜索中的文章
B Bellaver, JP Ferrari-Souza, L Uglione da Ros… - Neurology, 2021