作者
Torben Martinussen, Thomas H Scheike
发表日期
2002/6/1
期刊
Biometrika
卷号
89
期号
2
页码范围
283-298
出版商
Oxford University Press
简介
We present a new additive‐multiplicative hazard model which consists of two components. The first component contains additive covariate effects through an additive Aalen model while the second component contains multiplicative covariate effects through a Cox regression model. The Aalen model allows for time‐varying covariate effects, while the Cox model allows only a common time‐dependence through the baseline. Approximate maximum likelihood estimators are derived by solving the simultaneous score equations for the nonparametric and parametric components of the model. The suggested estimators are provided with large‐sample properties and are shown to be efficient. The efficient estimators depend, however, on some estimated weights. We therefore also consider unweighted estimators and describe their large‐sample properties. We finally extend the model to allow for time‐varying …
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