作者
Torben Martinussen, Stijn Vansteelandt
发表日期
2013/7
期刊
Lifetime data analysis
卷号
19
期号
3
页码范围
279-296
出版商
Springer US
简介
We study the situation where it is of interest to estimate the effect of an exposure variable on a survival time response in the presence of confounding by measured variables . Quantifying the amount of confounding is complicated by the non-collapsibility or non-linearity of typical effect measures in survival analysis: survival analyses with or without adjustment for typically infer different effect estimands of a different magnitude, even when is not associated with the exposure, and henceforth not a confounder of the association between exposure and survival time. We show that, interestingly, the exposure coefficient indexing the Aalen additive hazards model is not subject to such non-collapsibility, unlike the corresponding coefficient indexing the Cox model, so that simple measures of the amount of confounding bias are obtainable for the Aalen hazards model, but not for the Cox model. We argue …
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