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To evaluate the efficacy of autologous serum application for the treatment of persistent epithelial defect.

Prospective, clinical, noncomparative case series.

A total of 16 eyes were studied.

Autologous serum was prepared from the patients and diluted to 20% by saline. The patients were instructed to use the autologous serum six to ten times a day. The concentration of vitamin A, epidermal growth factor (EGF), and transforming growth factor-β (TGF-β) was measured at 1 week and 1 month stored in the refrigerator and 1 month and 3 months in the freezer.

Time to closure of epithelial defect.

Vitamin A, EGF, and TGF-β were stable during the 1 month in the refrigerator and 3 months in the freezer. Among 16 persistent epithelial defects, 7 (43.8%) healed within 2 weeks, 3 (18.8%) healed within 1 month, and the remaining 6 …